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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Adopted according to OECD SIDS or other official EU regulation procedures (public available peer reviewed source).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974

Materials and methods

Principles of method if other than guideline:
Method: other: P&G standard procedure #1; comparable or similar to OECD Guideline 401.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
68955-19-1 (purity 25%)
IUPAC Name:
68955-19-1 (purity 25%)
Details on test material:
- Name of test material (as cited in study report): No data
- Physical state: No data
- Analytical purity: 25% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
other: Cox CD
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2500, 3500, 4900 and 6850 mg/kg bw
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 010 mg/kg bw
Based on:
act. ingr.

Any other information on results incl. tables

LD50 (confidence limits): 3390 - 4740 mg/kg

MORTALITY
-Time of death: all deaths occurred within 24 hrs to 7 days after dosing

-Number of deaths at each dose:
2500 mg/kg:  0/10
3500 mg/kg:  5/10
4900 mg/kg:  6/10
6850 mg/kg: 10/10


CLINICAL SIGNS
>= 2500 mg/kg: slight to moderate decreased motor activity and  respiratory

 rate, blanching, abdominal griping and diarrhoea
>= 3500 mg/kg: slight degrees of haemorrhagic rhinitis; persistent 

symptoms and delayed deaths were noted up to seven days post-treatment
   6850 mg/kg: slight loss of corneal reflex and pupilary responses

NECROPSY FINDINGS
necropsy of survivors: no abnormalities

POTENTIAL TARGET ORGANS
-none

SEX-SPECIFIC DIFFERENCES
-none

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU