Diphenyl carbonate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes

Type of method:

flask method

Water solubility:

ca. 13 mg/L

Temp.:

20 °C

pH:

7.1

Details on results:

Stable: no
Degradation products: yes

Test substance hydrolyses in water generating phenol and carbon dioxide.
The measured concentrations of the test substance in water and the corresponding pH-values were: 
F1: 12.9 mg/l, pH=7.2
F2: 13.0 mg/l, pH=7.1
F3: 13.3 mg/l, pH=7.0

Conclusions:

The water solubility of diphenyl carbonate is ca. 13 mg/L at 20 °C and pH 7.1.
Diphenyl carbonate hydrolyses in water generating phenol and carbon dioxide (t1/2 = 40 hours).

Executive summary:

The water solubility of diphenyl carbonate was investigated in study which was conducted in accordance with the standardised guideline EU Method A.6. (flask method), with acceptable restrictions and under GLP conditions.

Three separate flasks were filled with solutions of diphenyl carbonate at the concentrations 499, 510 and 505 mg/L. These flasks were then agitated for 24, 48 and 72 hours at 30 °C, respectively, prior to all three being agitated at 20 °C for 24 hours.

It was concluded that due to the fact that the substance hydrolyses in water, the determination of the water solubility with this method is not appropriate. The stability of the concentrations (despite degradation of the test material due to hydrolysis) can be explained by the fact that additional test material is dissolved from the undissolved substance.

The water solubility of diphenyl carbonate is ca. 13 mg/L at 20 °C and pH 7.1.

Description of key information

The water solubility of diphenyl carbonate has been determined to be ca. 13 mg/L at 20 ° C, pH 7.1, EU Method A.6 (flask method), Bayer (2000)

Key value for chemical safety assessment

Water solubility:

13 mg/L

at the temperature of:

20 °C

Additional information

The endpoint is addressed with one key study (Bayer, 2000). The water solubility of diphenyl carbonate was investigated in study which was conducted in accordance with the standardised guideline EU Method A.6. (flask method), with acceptable restrictions and under GLP conditions. The study has therefore been a reliability score of 2, in accordance with the criteria for assessing data quality as set forth by Klimisch et al. (1997).

Three separate flasks were filled with solutions of diphenyl carbonate at the concentrations 499, 510 and 505 mg/L. These flasks were then agitated for 24, 48 and 72 hours at 30 °C, respectively, prior to all three being agitated at 20 °C for 24 hours.

It was concluded that due to the fact that the substance hydrolyses in water, the determination of the water solubility with this method is not appropriate. The stability of the concentrations (despite degradation of the test material due to hydrolysis) can be explained by the fact that additional test material is dissolved from the undissolved substance.

The water solubility of diphenyl carbonate is ca. 13 mg/L at 20 °C and pH 7.1.

 

Diphenyl carbonate hydrolyses in water, generating phenol and carbon dioxide (t1/2 = 39.9 h). Water solubility of phenol was assessed in a European Union Risk Assessment Report (European Chemicals Bureau, 2006). Water solubility of phenol is 84 g/L at 20 °C.