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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional ecotoxicological information
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Report on a review of information generated using (Q)SAR tools with QMRF and QPRF reporting

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Principles of method if other than guideline:
CRAFT (2009) and ECOSAR (2009) were used to investigate aspects relating to the environmental fate and ecotoxicity of diphenyl carbonate. First, the degradation products of diphenyl carbonate were predicted using CRAFT. Then, the degradation products were assessed in terms of their potential short-term aquatic toxicity to green algae.
GLP compliance:
no
Type of study / information:
Desk-based review of information generated through the use of (Q)SAR.

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenyl carbonate
EC Number:
203-005-8
EC Name:
Diphenyl carbonate
Cas Number:
102-09-0
Molecular formula:
C13H10O3
IUPAC Name:
diphenyl carbonate

Results and discussion

Any other information on results incl. tables

Diphenyl carbonate degradation products anticipated as “very likely” using CRAFT are predicted by EPI Suite ECOSAR as likely to have a green algae (96h) EC50 >1 mg/L.

Diphenyl carbonate degradation products predicted by CRAFT that could be of potential concern to algae by EPI Suite ECOSAR concern benzene structures with multiple hydroxyl groups where there is a hydroxygroup in 1,4 positions (e.g. 4-hydroxycatechol). These structures are predicted by ECOSAR as having a green algae (96h) EC50 value slightly below 1 mg/L due to presence of quinone/hydroquinone structural similarities. However, using the example of hydroquinone, algae test study results of hydroquinone reported in the ex-ECB ESIS database (2010) indicated EC50 >1 mg/L (although ECOSAR predicts <1 mg/L). For hydroquinone it is fish and daphnia results that are <1 mg/L resulting in R50 classification. By comparison fish and daphnia studies for diphenyl carbonate are >1 mg/L.

Overall, diphenyl carbonate degradation products are expected to have rapid ring opening, resulting in products that are expected to have green algae (96h) values of EC50 >>1 mg.

Applicant's summary and conclusion

Conclusions:
Based on the review of the predicted degradation products, it is not expected that diphenyl carbonate would have a toxicity to green algae (96 h) below 1 mg/L. This can be considered together with other information on diphenyl carbonate.
Executive summary:

Diphenyl carbonate degradation products anticipated as “very likely” using CRAFT are predicted by EPI Suite ECOSAR as having a green algae (96 h) EC50 >1 mg/L. Furthermore diphenyl carbonate degradation products are expected to have rapid ring opening, resulting in products that are expected to have green algae (96 h) values of EC50 >>1 mg. This information is deemed relevant for consideration as part of a weight-of-evidence during the classification and labelling of diphenyl carbonate.