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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to basic scientific principles.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
Reason / purpose for cross-reference:
read-across: supporting information
Reference
Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to basic scientific principles.
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Sex:
not specified
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Negative controls validity:
not applicable
Positive controls validity:
not applicable
Conclusions:
Interpretation of results: negative
Stoddard Solvent did not induce significant chromosomal abnormalities.
Executive summary:

This data is being read across from the source study that tested Stoddard solvent based on analogue read across.

Stoddard Solvent did not induce significant chromosomal abnormalities.

Data source

Reference
Reference Type:
publication
Title:
Proceedings of the Symposium, The toxicology of petroleum hydrocarbons
Author:
Conaway, C.C., Schreiner, C.A., Cragg, S.T.
Year:
1982
Bibliographic source:
The American Petroleum Institute

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
GLP compliance:
not specified
Type of assay:
chromosome aberration assay

Test material

Constituent 1
Reference substance name:
Stoddard solvent
EC Number:
232-489-3
EC Name:
Stoddard solvent
Cas Number:
8052-41-3

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
DMSO
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 0.087, 0.289, 0.868 mL/kg DMSO
Basis:
nominal conc.
Control animals:
yes, concurrent vehicle

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Negative controls validity:
not applicable
Positive controls validity:
not applicable

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative
Stoddard Solvent did not induce significant chromosomal abnormalities.
Executive summary:

Stoddard Solvent did not induce significant chromosomal abnormalities.