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EC number: 203-618-0 | CAS number: 108-80-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyanuric acid
- EC Number:
- 203-618-0
- EC Name:
- Cyanuric acid
- Cas Number:
- 108-80-5
- Molecular formula:
- C3H3N3O3
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triol
- Details on test material:
- - Name of test material (as cited in study report): Crude cyanuric acid
- Lot/batch No.: Lot 3-30-81
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Wilmington, MA. USA.
- Weight at study initiation: Males: 249 – 276 g; females: 181 – 202 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tap water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 397 mg/mL
- Amount of vehicle (if gavage): males ~0.7 ml; females ~0.5 ml
DOSAGE PREPARATION: The test material was ground into a powder and suspended in tap water at a concentration of 397 mg/ml. - Doses:
- 5000 mg/kg bw by gavage
- No. of animals per sex per dose:
- 10 (5 male and 5 female)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations 3 times within the first 8 hours and twice daily thereafter. Body weights recorded on day 0, 7 and 14.
- Necropsy of survivors performed: yes(day 15) - Statistics:
- None applied
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortalities occured
- Clinical signs:
- other: Clinical abnormalities were observed in 2 animals, one of each sex, including lack of faecal material in both animals and sedation, ataxia and piloerection, porphyrin around the nose . With the exception of body weight loss these effects subsided by the 4
- Gross pathology:
- No effects noted
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Cyanuric acid is not classified
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