Registration Dossier
Registration Dossier
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EC number: 203-618-0 | CAS number: 108-80-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyanuric acid
- EC Number:
- 203-618-0
- EC Name:
- Cyanuric acid
- Cas Number:
- 108-80-5
- Molecular formula:
- C3H3N3O3
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triol
- Details on test material:
- - Name of test material (as cited in study report): Crude Cyanuric aicd
- Substance type: Solid balls
- Lot/batch No.: 3-30-81
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Isaac’s Farm, Litchfield, Illinois, USA
- Age at study initiation: Young adult
- Weight at study initiation: 2.40 – 2.93 kg
- Diet (e.g. ad libitum): Provided ad libitum
- Water (e.g. ad libitum): Provided ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 82 ± 1 mg
- Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- 24, 48 and 72 h
- Number of animals or in vitro replicates:
- 6
- Details on study design:
-
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.3
- Reversibility:
- fully reversible within: 3 days
- Irritant / corrosive response data:
- The average of the Draize scores for 24, 48 and 72 h was 0.3. All irritation had subsided by the third day after exposure. No corneal or iridal involvement was observed.
Any other information on results incl. tables
Table 1: Primary eye irritation to rabbits - individual irritation scores
Animal number |
Observation day |
Cornea |
Iris |
Conjunctivae |
Total |
Average of 24, 48, 72 h |
01M01 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01M02 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01M03 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01F01 |
1 |
0 |
0 |
0 |
0 |
0.0 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01F02 |
1 |
0 |
0 |
2 |
2 |
0.7 |
2 |
0 |
0 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
||
|
|
|
|
|
|
|
01F03 |
1 |
0 |
0 |
2 |
2 |
1.3 |
2 |
0 |
0 |
2 |
2 |
||
3 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Cyanuric acid is not irritating to eyes
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