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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Rationale for reliability incl. deficiencies:
other: The activity of the Laboratory Department is certified according to the ISO 9001:2008 standard.

Data source

Reference Type:
other company data
Report date:

Materials and methods

Objective of study:
bioaccessibility (or bioavailability)
Test guideline
no guideline followed
Principles of method if other than guideline:
One liter of demineralised water has been adjusted to pH = 1.5 by adding HCl 37%; 300 ml of the previous solution has been spilled in one glass beaker and the temperature has been regulated at 37°C. Agitating sufficient quantity of the Ba-substance has been dissolved to reach a saturated solution keeping the temperature at 37 °C. After 15 minutes additional reaction time the solution has been filtered with preheated filtering equipment. The barium content in the filtrate has been determined by gravimetric analysis (the filtrate had for BaCl2*2H2O test a pH = 0.6).

The objective of this study is to assess the dissolution of chemical compounds in different artificial physiological media. The test media are selected to simulate relevant human-chemical interactions (as far as practical), i.e. contact of a test substance with skin, a substance entering the human body by inhalation or by ingestion into the gastro-intestinal tract. The amount dissolved of the test item is specified by the mass concentration of the substance in the test media under the applied test conditions. The total dissolved amount will be determined by measuring the total vanadium concentration in solution. Additionally, V(IV) and V(V) will be separated by HPLC and detected by ICP-MS. The concentration of possible further species (i.e. V(III)) will be determined indirectly by subtracting the concentrations of V(IV) and V(V) from the total dissolved concentrations.
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
barium(2+) dichloride dihydrate
EC Number:
Cas Number:
Molecular formula:
barium(2+) dichloride dihydrate
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): Barium chloride cristalli
-Chemical name: Barium chloride dihydrate
- Molecular formula: BaCl2 *2H2O
- Molecular weight: 244.26 g/mol
- Physical state: Solid, white powder
- Storage condition of test material: Ambient temperature, dark, dry and original containers
No further information on the test material was stated.

Test animals

other: in vitro (simulated human body fluids)

Results and discussion

Applicant's summary and conclusion

510.4 g/L barium dichloride dihydrate dissolves in a artificial gastic fluid of HCl solution (pH 1.5) at 37°C. After dissolution the pH value of the solution was: 0.8.