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EC number: 233-788-1 | CAS number: 10361-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2010-09-01
- Rationale for reliability incl. deficiencies:
- other: The activity of the Laboratory Department is certified according to the ISO 9001:2008 standard.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Objective of study:
- bioaccessibility (or bioavailability)
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One liter of demineralised water has been adjusted to pH = 1.5 by adding HCl 37%; 300 ml of the previous solution has been spilled in one glass beaker and the temperature has been regulated at 37°C. Agitating sufficient quantity of the Ba-substance has been dissolved to reach a saturated solution keeping the temperature at 37 °C. After 15 minutes additional reaction time the solution has been filtered with preheated filtering equipment. The barium content in the filtrate has been determined by gravimetric analysis (the filtrate had for BaCl2*2H2O test a pH = 0.6).
The objective of this study is to assess the dissolution of chemical compounds in different artificial physiological media. The test media are selected to simulate relevant human-chemical interactions (as far as practical), i.e. contact of a test substance with skin, a substance entering the human body by inhalation or by ingestion into the gastro-intestinal tract. The amount dissolved of the test item is specified by the mass concentration of the substance in the test media under the applied test conditions. The total dissolved amount will be determined by measuring the total vanadium concentration in solution. Additionally, V(IV) and V(V) will be separated by HPLC and detected by ICP-MS. The concentration of possible further species (i.e. V(III)) will be determined indirectly by subtracting the concentrations of V(IV) and V(V) from the total dissolved concentrations. - GLP compliance:
- no
Test material
- Reference substance name:
- barium(2+) dichloride dihydrate
- EC Number:
- 600-412-6
- Cas Number:
- 10326-27-9
- Molecular formula:
- BaCl2.2(H2O)
- IUPAC Name:
- barium(2+) dichloride dihydrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Barium chloride cristalli
-Chemical name: Barium chloride dihydrate
- Molecular formula: BaCl2 *2H2O
- Molecular weight: 244.26 g/mol
- Physical state: Solid, white powder
- Storage condition of test material: Ambient temperature, dark, dry and original containers
No further information on the test material was stated.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: in vitro (simulated human body fluids)
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- 510.4 g/L barium dichloride dihydrate dissolves in a artificial gastic fluid of HCl solution (pH 1.5) at 37°C. After dissolution the pH value of the solution was: 0.8.
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