Registration Dossier
Registration Dossier
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EC number: 217-164-6 | CAS number: 1760-24-3
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity data are available with the registration substance, N-(3-(trimethoxysilyl)propyl)ethylenediamine (CAS 1760-24-3, EC 217-164-6) for freshwater fish (Danio rerio), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata). Reliable long-term aquatic toxicity data are available for freshwater invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata). The relevant short-term values are:
Fish: LC50 (96 h): 484 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
Daphnia: EC50 (48 h): 66 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
Algae: ErC50 (72 h): 7.2 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
The relevant long-term values are:
Daphnia: NOEC (21 d): ≥0.81 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
Algae: NOErC (72 h): 2.5 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
The aquatic toxicity studies were conducted at pH 8 and above in many cases. The neutral form of the amine, i.e. the un-ionised form, is more toxic than the ionised form. This pattern of toxicity is consistent with ammonia, where the un-ionised form, NH3, is more toxic than the ionised form, NH4+. The difference in toxicity is due to bioavailability, where the un-ionised form can cross cell membranes more readily than the ionised form. Therefore, for waters having a pH closer to 7 it is likely that the study results overestimate the toxicity of the registered substance.
Reliable toxicity to aquatic microorganisms data are available for the registration substance:
Toxicity to microorganisms: EC50 (16 h): 54 mg/l and EC10 (16 h) 20 mg/l (Pseudomonas putida), expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine.
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