Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-164-6 | CAS number: 1760-24-3
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity data are available with the registration substance, N-(3-(trimethoxysilyl)propyl)ethylenediamine (CAS 1760-24-3, EC 217-164-6) for freshwater fish (Danio rerio), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata). Reliable long-term aquatic toxicity data are available for freshwater invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata). The relevant short-term values are:
Fish: LC50 (96 h): 484 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
Daphnia: EC50 (48 h): 66 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
Algae: ErC50 (72 h): 7.2 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
The relevant long-term values are:
Daphnia: NOEC (21 d): ≥0.81 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
Algae: NOErC (72 h): 2.5 mg/l, expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine
The aquatic toxicity studies were conducted at pH 8 and above in many cases. The neutral form of the amine, i.e. the un-ionised form, is more toxic than the ionised form. This pattern of toxicity is consistent with ammonia, where the un-ionised form, NH3, is more toxic than the ionised form, NH4+. The difference in toxicity is due to bioavailability, where the un-ionised form can cross cell membranes more readily than the ionised form. Therefore, for waters having a pH closer to 7 it is likely that the study results overestimate the toxicity of the registered substance.
Reliable toxicity to aquatic microorganisms data are available for the registration substance:
Toxicity to microorganisms: EC50 (16 h): 54 mg/l and EC10 (16 h) 20 mg/l (Pseudomonas putida), expressed in terms of the concentration of the silanol hydrolysis product, N-(3-(trihydroxysilyl)propyl)ethylenediamine.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
