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Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No data on materials and methods; the authors reference to a publication which is written in Russian language.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988

Materials and methods

Principles of method if other than guideline:
Method is described in: "Problems of industrial toxicology, Editorial section of the managing department of the Secretariat of CMEA." Title: "Methodological instructions for the organization of studies for the substantiation of standards of harmful substances in the air of the working zone" (in Russian)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
12539-71-8
Cas Number:
12539-71-8
IUPAC Name:
12539-71-8
Details on test material:
Name of test material (as cited in study report): zinc carbonate basic monohydrate (2 ZnCO3 . 3Zn(OH)2 . H2O))

Test animals

Species:
other: rabbit, guinea pig, rat
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period:
the reaction of the skin is recorded 1 and 16 h after a single application
Number of animals:
no data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: all animals tested
Time point:
other: 1 h an 16 h
Score:
ca. 0
Reversibility:
other: not applicable
Remarks on result:
other: The results of the study (irritation effects) are only described (without the presentation of numbers). It is stated that the test substance does not show an irritative effect on the skin.

Applicant's summary and conclusion