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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
specific investigations: other studies
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Correlation of chemical structure with reproductive aand developmental toxicity as it relates to the use of the threshold of toxicological concern
Author:
Laufersweiler MC, Gadagbui B, Baskerville-Abraham IM, maier A, Willis A, Scialli AR, Carr GJ, Felter SP, Blackburn K, Daston G
Year:
2012
Bibliographic source:
Reg Toxicol Pharmacol 62 (2012) 160-182

Materials and methods

Principles of method if other than guideline:
An examination was performed if the threshold of toxicological concern (TCC) derrived from repeated dose toxicity studies is also protective for reproductive/developmental toxicity as well. In this examination Cyclohexylbenzothiazol-2-sulphenamide (CAS 95-33-0) was included.
Type of method:
other: Evaluation of literature data.
Endpoint addressed:
toxicity to reproduction / fertility
developmental toxicity / teratogenicity

Test material

Constituent 1
Chemical structure
Reference substance name:
N-cyclohexylbenzothiazole-2-sulfenamide
EC Number:
202-411-2
EC Name:
N-cyclohexylbenzothiazole-2-sulfenamide
Cas Number:
95-33-0
Molecular formula:
C13H16N2S2
IUPAC Name:
N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
Details on test material:
No data

Results and discussion

Details on results:
The present analysis indicates that, for each Cramer Class, the reproductive and developmental endpoints would be protected at the corresponding general TTC tiers derived by Munro et al., Food Chem. Toxicol. 34, 829-867 (1996).

Applicant's summary and conclusion