Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-411-2 | CAS number: 95-33-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
- Reference Type:
- publication
- Title:
- Acute toxicologic evalaution of Santocure vulcanization accelerator
- Author:
- Randall, D.J. and Bannister, R.M.,
- Year:
- 1 990
- Bibliographic source:
- Acute Toxic. Data 1 (2), 105-106
Materials and methods
- Principles of method if other than guideline:
- 100 mg of finely ground test substance was placed into the conjunctival sac of 6 New Zealand albino male and female rabbits. A 7-d observation period followed application. Eye responses were scored in accordance with the Federal Hazardous Substance Act, 21 CFR, § 191.12 (1964).
- GLP compliance:
- no
Test material
- Reference substance name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- EC Number:
- 202-411-2
- EC Name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- Cas Number:
- 95-33-0
- Molecular formula:
- C13H16N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
- Details on test material:
- test substance: Santocure CBS
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 24, 48, 72, 168 h
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.8
- Max. score:
- 110
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: at 24 h: slight erythema and moderate discharge
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5.66
- Max. score:
- 20
- Reversibility:
- fully reversible within: 40 hours
- Remarks on result:
- other: (conjunctiva + chemosis + discharge) x 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 5.66
- Max. score:
- 20
- Reversibility:
- not fully reversible within: 48 h
- Remarks on result:
- other: (conjunctiva + chemosis + discharge) x 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible
Any other information on results incl. tables
Number of animals: 6
Test results:
Draize score: 1.8/110
1 hr: slight erythema, copious discharge
24 h: slight erythema in five instances, moderate discharge
The test substance was slightly irritating to the rabbit eye, 1.8/110.0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an eye irritation test with six New Zealand albino rabbits the test substance caused slightly and transient erythema of the conjunctivae. No effects were noted after 48 hours. An irritation score of 1.8 (Draize score: 1.8/110) was indicated (Monsanto 1973).
- Executive summary:
In an eye irritation test with six New Zealand albino rabbits the test substance caused slightly and transient erythema of the conjunctivae. No effects were noted after 48 hours. An irritation score of 1.8 (Draize score: 1.8/110) was indicated (Monsanto 1973).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
