Registration Dossier
Registration Dossier
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EC number: 202-411-2 | CAS number: 95-33-0
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Remarks:
- embryonic mortality, mutagens
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: unsuitable test system, incomplete and inexact data on study design.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of Vulcanization accelerators on embryonic mortality in rats
- Author:
- Aleksandrov, S.E.:
- Year:
- 1 982
- Bibliographic source:
- Bull. Exp. Biol. Med. 93, 87-88
Materials and methods
- Principles of method if other than guideline:
- Rats were applied Santocure (N-cyclohexylbenzothiazole-2-sulphenamide) before or during pregnancy to determine the primary mechanism of embryonic mortality (mutagenic action on gametes at the beginning of embryogenesis, toxic action of the chemical on the embryo or hormonal disturbances in the mother).
- GLP compliance:
- no
- Type of assay:
- other: embryonic mortality
Test material
- Reference substance name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- EC Number:
- 202-411-2
- EC Name:
- N-cyclohexylbenzothiazole-2-sulfenamide
- Cas Number:
- 95-33-0
- Molecular formula:
- C13H16N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine
- Test material form:
- solid: particulate/powder
- Remarks:
- Beige
- Details on test material:
- Test substance: Santocure CBS
- Analytical purity: 96.2 %
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- Females: twice (1st, 3rd day of oestrus), males (interval of 3 days)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/kg bw
Basis:
- No. of animals per sex per dose:
- 10 females treatment group, control: 25 females
Results and discussion
Test results
- Sex:
- male/female
Any other information on results incl. tables
No increased postimplantation embryonic mortality (= "index of mutagenicity").
Applicant's summary and conclusion
- Executive summary:
Rats were applied Santocure (N-cyclohexylbenzothiazole-2-sulphenamide) before or during pregnancy to determine the primary mechanism of embryonic mortality (mutagenic action on gametes at the beginning of embryogenesis, toxic action of the chemical on the embryo or hormonal disturbances in the mother). On the basis of these experimental results it was not possible to determine precisely which mechanism caused the rise in embryonic mortality and the decrease in weight of the fetuses.
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