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Registration Dossier
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EC number: 205-426-2 | CAS number: 140-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
A reliable acute oral toxicity study according OECD 401 was conducted in 5 Wistar rats/sex at doses of 3160, 3980, 4495 and 5010 mg/kg bw 4-(1,1,3,3-tetramethylbutyl)phenol in paraffin (Sasol, 1984). A second OECD 401 study was conducted in 5 SD rats/sex at a limit dose of 2000 mg/kg in arachis oil (Safepharm Laboratories 1991). In addition a poorly documented study from Rohm & Haas (1973) reports the oral exposure of 6 albino rats/sex to a limit dose of 5g/kg bw.
In a poorly documented inhalation study 6 albino rabbits were exposed to 116 mg/l octylphenol in isopropyl myristate (Rohm & Haas, 1973). The same study investigated acute dermal toxicity using 6 rabbits (3 intact and 3 abraded). Octylphenol was administered at a limit dose of 2.0 g/kg bw. Dermal toxicity was also assessed in an OECD 402 study (BASF 1981) at doses of 1000 and 2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 040 mg/kg bw
Additional information
Both OECD 401 guideline studies report a LD50 above 2000 mg/kg bw. From the non-limit dose study a LD50 (rat) of 4040 (3640-4484) mg/kg bw was derived. A poorly documented Rhom&Haas study reports a LD100 of 5000 mg/kg bw.
In an acute inhalation toxicity study, a group of 6 adult albino rats were exposed by inhalation to p-octylphenol (89%) in isopropyl myristate for 1 hour at a concentration of 116 mg/L. All 6 animals died on day 1. The concentration was too high to derive an LD50. For classification purposes a limit dose of 20 mg/l would be used to determine toxicity by inhalation.
Dermal toxicity was assessed in an OECD 402 study (BASF, 1981). The dermal application of 2000 mg/kg bw for 24 h to 3 rabbits/sex did not cause mortality and no internal abnormalities within a 7 day observation period. This finding was confirmed by a similar study (Rhom&Haas, 1973).
Justification for classification or non-classification
No symbol and risk phrase are required according to EEC labelling regulations - based on a low acute toxicity by ingestion (LD50 > 2000 mg/kg), and for dermal exposure (LD50 > 2000 mg/kg).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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