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Description of key information

Nickel carbonate hydroxide is classified according to Annex I to Directive 67/548/EEC with Xn; R 20/22

Key value for chemical safety assessment

Additional information

Oral:

There is one acute oral LD50 study for nickel carbonate which gives values of 625 mg Ni/kg for male rats and 402 mg Ni/kg for female rats (approximately 1263 and 812 mg nickel carbonate/kg). Based on the measured value, classification of nickel carbonate hydroxide as Xn; R22 (GHS: Acute Tox. 4) is justified. This reflects the differences in water solubility of the carbonate (mg/l) compared to the soluble nickel salts (>100 g/l) (EU C&L Dossier and the OECD SIDS draft 2007).

Inhalation:

There is no data available for the acute inhalation toxicity of nickel carbonate and -hydroxide.

Absorption of soluble nickel salts following inhalation is considerably greater than after oral

administration. The absorption of less soluble salts is less. A value of 100% absorption has

been agreed for the risk assessment, based on the Industry derogation statement to a “worst case”

comparison. Based on the proposal to classify the substance for acute oral toxicity,

classification for acute inhalational toxicity (R-20) is considered appropriate (GHS: Acute Tox. 4) (EU C&L Dossier and the OECD SIDS draft 2007).

Dermal:

There is no data available for the acute dermal toxicity of nickel carbonate and -hydroxide. In the view of the poor absorption by this route acute toxicity is expected to be low (EU C&L Dossier and the OECD SIDS draft 2007).

Justification for classification or non-classification