Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-875-2 | CAS number: 13530-50-2
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 403
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method B.2
- Deviations:
- no
- Principles of method if other than guideline:
- The particle size distribution of the test material was determined using a Mercer 7 stage cascade impactor (Model 02-130, In-Tox . Products Inc, Alberquerque, New Mexico, USA) via gravimetric analysis of the test item deposited on each stage of the cascade impactor.
MMAD and GSD were calculated. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of distribution:
- counted distribution
- Mass median aerodynamic diameter:
- > 2.56 - < 2.79 µm
- Percentile:
- D50
- Mean:
- > 2.56 - < 2.79 µm
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- Conclusions:
- The mass median diameter of the particles was > 2.56 and < 2.79µm.
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The determination of particle size was made by a screening process with a specific mesh size in an air jet made by subpressure.
- GLP compliance:
- no
- Type of method:
- sieving
- Type of distribution:
- volumetric distribution
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- >= 15 %
- Conclusions:
- The particle size distribution shows that ≥15% of particles were < 100µm in diameter. Therefore, the Particle size distribution indicates substance is an inhalation risk (a significant proportion of the particles are present at < 100 µm).
Referenceopen allclose all
Description of key information
Particle Size Distribution: > 15 % Particles < 100 µm (Weight of Evidence)
Additional information
The substance is manufactured as a powder. The available data indicate that the substance contains 15% particles < 100 µm in diameter and therefore, the substance is considered to be inhalable (Schongart (2010), Schuler (2010)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
