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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Data came from the SIDS dossier on CAS No. 81-11-8 that was accepted at SIAM 4 and posted on the OECD website.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1992

Materials and methods

Principles of method if other than guideline:
no details given
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-diaminostilbene-2,2'-disulphonic acid
EC Number:
201-325-2
EC Name:
4,4'-diaminostilbene-2,2'-disulphonic acid
Cas Number:
81-11-8
Molecular formula:
C14H14N2O6S2
IUPAC Name:
2,2'-ethene-1,2-diylbis(5-aminobenzenesulfonic acid)

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male
Details on test animals or test system and environmental conditions:
The rats were housed in groups of 3-6 animals and were allowed free access to food and water.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Single oral doses of 1000 or 3000 mg/kg were given to an unlisted number of animals.
Doses:
Single oral doses of 1000 or 3000 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Toxicity was assessed 24 hour after application.
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Mortality:
no data
Clinical signs:
other: No signs of toxicity were noted.
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
other: not classified as harmful/toxic according to the CLP Regulation (EC) No.1272/2008
Conclusions:
LD50 (male) > 3000 mg/kg bw
Executive summary:

The acute oral toxicity study was conducted by using the given test chemical in Male Sprague-Dawley rats at the concentrations of 1000 and 3000 mg/kg bw. No signs of toxicity were noted. 


LD50 (male) > 3000 mg/kg bw
Based on the study results, the substance is considered to be not toxic to rats via oral application.