Silicic acid, aluminum sodium salt

Sediment toxicity

Link to relevant study record(s)

Reference

Endpoint:

sediment toxicity: long-term

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: ISO 10872

GLP compliance:

yes

Specific details on test material used for the study:

Test item: Silicic acid Aluminium Magnesium Sodium Salt
CAS No.: 12040-43-6

Test organisms (species):

Caenorhabditis elegans

Details on test organisms:

Caenorhabditis elegans, strain N2; J1 at test begin (mean initial body length: 262 (± 15 SD) µm)

Study type:

laboratory study

Type of sediment:

artificial sediment

Remarks:

Formulated sediment (according to ISO 10872) spiked with dispersions of the test item in water

Limit test:

no

Duration:

96 h

Test temperature:

19.8 – 20.3 °C

Nominal and measured concentrations:

Test concentrations:
nominal: 50, 200, 400, 800, 1600, 3200, 5000 mg/kg dry weight

Reference substance (positive control):

yes

Remarks:

Benzylcetyldimethylammonium chloride monohydrate (BAC-C16; 15 mg/l in aqueous medium)

Key result

Duration:

96 h

Dose descriptor:

LOEC

Effect conc.:

> 5 000 mg/kg sediment dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Key result

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 5 000 mg/kg sediment dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Validity criteria fulfilled:

yes

Conclusions:

No inhibitory toxic effects occurred on growth and reproduction of C. elegans up to nominal concentrations of 5000 mg/kg sediment dry weight (dw). Thus a NOEC of 5000 mg/kg sediment dw based on nominal concentrations was determined. Between 200 and 3200 mg/kg sediment dw, significant stimulatory effects on reproduction occurred.

Description of key information

No inhibitory toxic effects occurred on growth and reproduction of C. elegans up to nominal concentrations of 5000 mg/kg sediment dry weight (dw) with the read-across substance Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS). Thus, a NOEC of 5000 mg/kg sediment dw based on nominal concentrations was determined. Between 200 and 3200 mg/kg sediment dw, significant stimulatory effects on reproduction occurred.

Additional information

Since no studies investigating the sediment toxicity of Silicic acid, aluminum sodium salt (CAS 1344-00-9, NAS) are available, a read-across to the structurally related Silicic acid, aluminum magnesium sodium salt (CAS 12040-43-6, SMAS) was conducted. This read-across is justified within the analogue justification in IUCLID Section 13.