Registration Dossier
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EC number: 231-821-4 | CAS number: 7757-83-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- other: Any kind of reliability rating is not considered to be applicable, since human studies/reports are not conducted/reported according to standardised guidelines
- Rationale for reliability incl. deficiencies:
- other: Review article about disodium disulfite covering different endpoints including sensitisation. This endpoint study record summarises the information about sensitisation.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Disodium disulphite
- Author:
- Anonymous
- Year:
- 2 001
- Bibliographic source:
- OECD SIDS
Materials and methods
- Type of sensitisation studied:
- respiratory
- skin
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): disodium disulfite
Method
- Type of population:
- general
- occupational
- Details on study design:
- no data
Results and discussion
- Results of examinations:
- In a few cases allergic contact dermatitis as well as positive patch-testing was observed (Jacobs, 1992; Apetato, 1986; Sokol, 1990; Petersen, 1990; Larame, 1989; Vestergaard and Andesen, 1995)*. Given the wide-spread use, the number of cases is considered to be low.
Disodium disulfite is not irritating to the skin but irritating to the eyes. It is not considered as skin sensitizer and also unlikely to induce respiratory sensitization but may enhance symptoms of asthma in sensitive individuals.
*References:
- Jacobs M C, R.J.G. Rycroft. Contact dermatitis and asthma from sodium metabisulfite in a photographic technician. Contact Dermatitis. 33, 65-66, 1995.
- Apetato M, M.S.J. Marques. Contact dermatitis caused by sodium metabisulfite. Contact Dermatitis. 14, 194, 1986.
- Sokol W.N, I.B. Hydick. Nasal congestion, urticaria, and angioedema, caused by IgE-mediated reaction to sodium metabisulfite. J. Allerg Clin Immunol. 65, 233-238, 1990.
- Petersen P.E, R.B.Evans, M.A.Johnstone, W.R Handerson. Evaluation of ocular hypersensitivity to dipivalyl epinephrine by component eye-drop testing. J Allergy Clin Immunol. 85, 954-958, 1990.
- Larame B, P.M. Bedard, J. Hebert. Contact dermatitis to sulfating agents. J Allergy Clin Immunol. 28, 197, 1989.
- Vestergaard LL., K. E Andersen. Am. J. Contact Dermatitis. 6, 174-175, 1995
Applicant's summary and conclusion
- Conclusions:
- The following conclusion was given in the review: in a few cases allergic contact dermatitis as well as positive patch-testing was observed. Given the wide-spread use, the number of cases is considered to be low.
Disodium disulfite is not irritating to the skin but irritating to the eyes. It is not considered as skin sensitizer and also unlikely to induce respiratory sensitization but may enhance symptoms of asthma in sensitive individuals.
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