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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

According to the measured BCF the substance does not significantly accumulate in organisms.

Key value for chemical safety assessment

BCF (aquatic species):
3.9 L/kg ww

Additional information

To determine the bioaccumulative potential of TEA (CAS 102 -71 -6) to aquatic organisms, a study conducted according to the OECD test guideline 305 was performed. Cyprinus carpio was used as test species. The determined BCF in this study was < 3.9 at a concentration of 0.25 mg/l whereas at a concentration of 2.5 mg/l a BCF < 0.4 was measured (MITI 1992).

 

This experimental result is supported by reliable data calculated by several estimation models. The table below lists all applied (Q)SAR models, the estimated BCF values and basic information on the applicability domain (AD). Detailed information on the model’s results and the AD are given in the endpoint study records of IUCLID Chapter 5.3.1. The selected models comply with the OECD principles for (Q)SAR models.

 

Summary of relevant information on aquatic bioaccumulation: Predicted BCF values for applied QSAR models sorted by BCF: (AD = Applicability Domain)

Model

BCF

In AD

Restraints

US EPA T.E.S.T. v4.2.1: Bioaccumulation: Consensus method

0.5

no

Based on the absolute mean errors (MAE) of the Consensus submodel, the confidence in the prediction is low

BCFBAF v3.01 (EPI Suite v4.11): Arnot-Gobas BCF, upper trophic, incl. biotransformation

1.3

no

As the substance ionizes at physiologically relevant pH, the estimation may be less accurate.

BCF Read-Across v1.1.0 (VEGA v1.1.0)

1.3

yes

-

Meylan v1.0.3 (VEGA v1.1.0)

3

no

- Based on the global AD index, the reliability of the prediction is low (descriptors for this compound have values outside the descriptor range of the compounds of the training set)

CAESAR v2.1.14 (VEGA v1.1.0)

3

yes

-

BCFBAF v3.01 (EPI Suite v4.11): Arnot-Gobas BCF, upper trophic, incl. biotransformation of zero

3.2

no

As the substance ionizes at physiologically relevant pH, the estimation may be less accurate.

BCFBAF v3.01 (EPI Suite v4.11): Meylan et al. (1997/1999)

3.6

yes

-

BCF baseline model v.03.10 (OASIS Catalogic v5.13.1): incl. mitigating factors

2.5

yes

-

BCF baseline model v.03.10(OASIS Catalogic v5.13.1): not considering mitigating factors

9.2

yes

-

 

Considering all reliable models applied the estimated BCF values range from 1.3 to 9.2 L/kg. Based on the available information on the log Kow (log Kow = -2.3 at pH 7.1; measured; BASF AG, 1991) and supported by reliable calculated data, it can be concluded that significant accumulation in organisms is not to be expected.