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Long-term toxicity to aquatic invertebrates

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Description of key information

With high probability 2,2',2"-nitrilotriethanol has no chronic effects to aquatic invertebrates.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
16 mg/L

Additional information

To determine the chronic toxicity of 2,2',2"-nitrilotriethanol to aquatic invertebrates, a non-GLP reproduction toxicity study was performed using Daphnia magna as test species. The test followed a method of the German Federal Environmental Agency which is similar to the OECD TG 211. The test was designed as a semi-static procedure with closed vessels and exposure period of 21 days. Test concentrations were analytically verified and deviated less than 20% from nominal concentrations. Parental mortality, number of offspring per animal and first appearance of offspring were determined. The most sensitive endpoint was parental mortality. The 21 -d NOEC for parental mortality was determined to be 16 mg/L. The 21 -d NOEC for reproduction was 125 mg/L, the NOEC for appearance of first offspring was 250 mg/L (Kuehn et al./UBA 1989; Kuehn et al., 1988).

Therefore, it can be concluded that chronic effects are not expected.