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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
other: Read across from analogue substance
Adequacy of study:
key study
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not a guideline study; some details on methodology, but concentration of test substance that the animals were exposed to is not reported. Indicated only as "saturated air".

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1962

Materials and methods

Principles of method if other than guideline:
Exposure to concentrated vapour is continued for time periods in a logarithmic series with a ratio of the two extending from 15 minutes to 8 hours until the inhalation period killing about half the number of rats within 14 days of observation is defined.
GLP compliance:
no
Test type:
fixed concentration procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulphonic acid
EC Number:
202-638-7
EC Name:
Benzenesulphonic acid
Cas Number:
98-11-3
Molecular formula:
C6H6O3S
IUPAC Name:
benzenesulphonic acid
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
For exposures of 2, 5 or 10 minutes, a static technique was used by saturating the air with 50-100 g of test substance for 24 hours in a closed chamber. For exposures beyond 10 minutes a flowstream of saturated vapour was used.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 0.25 - <= 8 h
Concentrations:
Not reported. Air was saturated with 50-100 g of test substance
No. of animals per sex per dose:
3
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: no
- Other examinations performed: none reported

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
>= 50 - ca. 100 other: mg
Based on:
test mat.
Exp. duration:
8 h
Mortality:
3 of 6 animals died within 14 days after an 8 hour exposure. No deaths were reported for shorter duration exposures (i.e, 15, 30, 45 minutes; and 1, 2 and 4 hours).

Applicant's summary and conclusion

Conclusions:
LC50 = 50 g
Executive summary:

The acute inhalation toxicity of Benzene sulphonic acid was assessed with a test where only few details are available. Based on the results, 3 of 6 animals died within the 14-day observation period following an 8 hour exposure to a saturated air vapour of test substance. Concentration of test substance that the animals were exposed to is not reported, only indication as "saturated air".