Registration Dossier
Registration Dossier
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EC number: 232-094-6 | CAS number: 7786-30-3
Endpoint summary
Administrative data
Description of key information
For the 3 trophic levels, several studies on the short-term toxicity are available and one study is available on the long-term toxicity for invertebrates:
Fishes :
Short-term acute toxicity of MgCl2 tests have been performed on freshwater fathead minnows (Pimephales promelas), saltwater Mysid shrimp (Mysidopsis bahia), saltwater sheepshead minnows (Cyprinodon variegatus), and saltwater inland silverside minnows (Menidia beryllina). All the observed LC50 were higher than 100 mg/L. The lowest LC50 value was obtained for freshwater fathead minows (Pimephales promelas, LC50 = 2119 mg MgCl2/L) and the lowest LC50 value was obtained for Menidia beryllina which was the most sensitive saltwater fish (LC50 =10968 mg MgCl2/L). No reliable studies are available for chronic toxicity of MgCL2 to freshwater fish.
Invertebrates :
Reliable data are available on the acute and chronic effect of MgCl2 on aquatic invertebrates in both freshwater and marine water, including Daphnia magna (EC50 = 548 mg MgCl2/L, NOEC = 160 mg MgCl2/L), Ceriodaphnia dubia (EC50 = 1328 mg MgCl2/L) and Americamysis bahia (EC50 = 3259 mg MgCl2/L). All reliable LC50 values were higher than 100 mg/L. The lowest 48h-LC50 value was obtained for Daphnia magna for freshwater (EC50 = 548 mg MgCl2/L for freshwater and for the Americamysis bahia for marine invertebrates (EC50 = 3259 mg MgCl2/L). A NOEC = 160 mg MgCl2/L in the chronic test was observed for the daphnia magnia.
Algae :
A GLP guideline study was performed to assess the acute toxicity of Magnesium Chloride hexahydrate to the Single Cell Green Algae Desmodesmus subspicatus in a limit test (100 mg MgCl2 6H20/L). The 72h ErC50 was found to be >100 mg MgCl2 6H2O/L and no mortalities or adverse effects were noted at this limit test concentration: NOEC ≥ 100 mg of MgCl2 6H2O/L. According to the limit of the test methodology, the EC50 and the NOEC are unbounded values. Therefore, these unbounded EC50 and NOEC values for algae was not taken into account for the PNEC derivation due to its high degree of uncertainty.
A further literature study (et al.,1965) which assessed the toxicity of Magnesium Chloride to the algal species Chlorella vulgaris reports a NOEC of 980 mg Mg/L. In addition, two other data present two EC50s to Scenedesmus subspicatus of 562 and 1195 mg Mg/L. These three last data were not judged as reliable data since insufficient documentation on the test conditions are available to judge their reliability.
Therefore, the lowest short and long-term studies taken into account from all conducted studies were observed for Daphnia magna:
- Short-term : 48h LC50= 548 mg of MgCL2/L
- Long-term : 21d NOEC = 160 mg of MgCL2/L
Additional information
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