Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to other aquatic organisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Additional information

Toxicity to other aquatic organisms

Toxicity to other aquatic organisms

High quality acute toxicity values are available for different species, with the lowest EC50being 0.146 mg Ni/L for Xenopus laevis(Hopfer et al., 1991) and the highest EC50being 3.740 mg Ni/L forBufo terrestris(Fort et al., 2006). The LC50values range from 0.420 mg Ni/L forAmbystoma opacum(Birge et al., 1978) to 21.42 mg Ni/L forAmbystoma opacum(Hopfer et al, 1991).



NOEC/L(E) C10 data are available for different species of amphibians, with values ranging from 0.084 µg Ni/L to 13.15 mg Ni/L, both values fromXenopus laevis(Hopferet al., 1991).

The following table indicates those NOEC or EC10 values of high quality that have been carried forward for the HC5 & PNEC derivation


  Key Study

(freshwater amphibians)

Selected values for the most sensitive endpoints used for derivation of the freshwater HC5



Value (s) (ug/L)

Hopfer et al., 1991

Xenopus laevis



Fort et al., 2004

Xenopus laevis



Bufo terrestris



Gastrophryne carolensis