Nickel dinitrate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Meets generally accepted scientific methods with sufficient documentation. Relevant exposure to submission substance, adequate detail on exposure and sampling methods. (A detailed description of the scoring criteria can be found in the .pdf document attached to the 'Exposure Scoring Rationale Document' record at the beginning of Section 7.10.5).

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1987

Materials and methods

Type of study / information:

Examination of Ni exposure in at American Cyanamid, Indiana, USA

Endpoint addressed:

not applicable

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

No standard guideline followed. Details of study provided below.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Nickel dinitrate

EC Number:

236-068-5

EC Name:

Nickel dinitrate

Cas Number:

13138-45-9

Molecular formula:

Ni(NO3)2

IUPAC Name:

nickel(2+) dinitrate

Details on test material:

- Name of test material (as cited in study report): Nickel dinitrate
- Molecular formula (if other than submission substance): not different than submission substance
- Molecular weight (if other than submission substance): not different than submission substance
- Smiles notation (if other than submission substance): not different than submission substance
- InChl (if other than submission substance): not different than submission substance
- Structural formula attached as image file (if other than submission substance): not different than submission substance
- Substance type: nickel oxide powders
- Other details on test material not reported or not applicable

Method

Ethical approval:

not applicable

Details on study design:

NIOSH responded to a request for investigation of Nickel exposure at the American Cyanamid Plant in Michigan City, Indiana. Air samples were
collected and analyzed for 28 metals including nickel.

Exposure assessment:

measured

Details on exposure:

TYPE OF EXPOSURE: airborne exposure to nickel powders and dusts

TYPE OF EXPOSURE MEASUREMENT: Area air sampling and personal sampling, Ni speciation not conducted.

EXPOSURE LEVELS: 0.004 to 0.29 mg/m3 total Ni

EXPOSURE PERIOD: sample time between 352 and 462 minutes

POSTEXPOSURE PERIOD: none

DESCRIPTION / DELINEATION OF EXPOSURE GROUPS / CATEGORIES: none

Results and discussion

Results:

Ni exposure exceeded the NIOSH recommended exposure limit (0.015 mg/m3)

Applicant's summary and conclusion

Conclusions:

Ni concentrations ranged between 0.004 to 0.29 mg/m3 total Ni.

Executive summary:

STUDY RATED BY AN INDEPENDENT REVIEWER.

(A detailed description of the scoring criteria can be found in the .pdf document attached to the 'Exposure Scoring Rationale Document' record at the beginning of Section 7.10.5).