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Long-term toxicity to aquatic invertebrates

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Description of key information

The 21d-NOEC of the structurally related analogue D-Glucitol (Sorbitol), propoxylated (CAS 52625-13-5) in a OECD 211 guideline study is 10 mg/l (nominal) for all endpoints.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
10 mg/L

Additional information

Chronic toxicity of the structurally related analogue D-Glucitol (Sorbitol), propoxylated (CAS 52625-13-5) to invertebrates has been investigated in a reproduction test with Daphnia magna following the OECD guideline 211 using semi-static exposure. No effects were observed at the maximum concentration test (10 mg/l) and the NOEC are reported at 10 mg/l (nominal) for reproduction and mortality. Exposure concentrations were verified by mean of HPLC-MSD and were ranging between 73.3 and 100% of the nominal concentrations.

Hypothesis for the read-across approach:

Group:Succhrose, propoxylated; Propylidynetrimethanol, propoxylated; Glycerol, propoxylated; D‑Glucitol, propoxylated; Propane-1,2-diol, propoxylated; Pentaerythritol, propoxylated; 2,2',2''‑Nitrilotriethanol, propoxylated; Trimethylolpropane, ethoxylated; Diethylene glycol, propoxylated; Ethylene glycol, propoxylated; Diethanolamine, propoxylated.

The substance is member of a group of chemicals with similar chemical structure and physical behaviour:

1.) Chemical similarity: All of these substances have terminal OH-groups and ether-linkages as common structural features. Thus, the substances differ from each other only in the identity/type of starter molecule (aliphatic alcohols with 2 to 8 hydroxy functions) used and its associated bonding with the alkoxylate repeating units. Typically the products are substances with a range of Ethyleneoxide or Propyleneoxide units (1 -12.5) added to starter molecules. All substances are characterised by a molecular weight distribution of ca. 150 - 1000. The common function of the members of the group is to allocate a high number of hydroxy functions which are intended to react with e.g. an isocyanate.

2.) Physical behaviour: All members of the group are liquids with elevated viscosity, high solubility in water (> 100 g/L) and a low vapour pressure (<10E-04 hPa).