Registration Dossier
Registration Dossier
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EC number: 500-029-3 | CAS number: 9049-71-2 1 - 16.5 moles propoxylated
Endpoint summary
Administrative data
Description of key information
Acute toxicity via oral route were determined as > 2000 mg/kg bw (Bayer study) and > 5000 mg/kg bw (Dow study). The acute toxicity via the dermal route of exposure was > 5000 mg/kg bw.
Key value for chemical safety assessment
Additional information
In an acute oral toxicity study according to OECD Guideline 401, 5 male and 5 female Wistar rats were exposed to 2000 mg/kg bw. No clicinal signs were observed, resulting in a LD50 > 2000 mg/kg bw (Bayer, 1995).
In an acute oral toxicity study according to Federal register, august 22, 1978, 43:37355-6, male and femal Sprague-Dawley rats were exposed to 0, 650, 1250, 2500, 5000 mg/kg bw (6 animals per sex per dose). No clinical signs were observed, resulting in a LD50 > 5000 mg/kg bw (Dow, 1982).
In an acute dermal toxicity study according to OECD Guideline 434, 4 male and 4 female New Zealand White rabbits were exposed to 5000 mg/kg bw. No clinical signs were observed, resulting in a LD50 > 5000 mg/kg bw (Dow, 1982).
Justification for classification or non-classification
LD50 values for oral (> 2000 mg/kg bw or >5000 mg/kg bw) and dermal route (>5000 mg/kg bw) do not warrant classification according to the relavent criteria in the EU.
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