Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Sucrose, propoxylated was tested according to OECD Guideline 471 (Bacterial reverse mutation assay). There were negative findings both with and without metabolic activation.

The results from a mammalian point mutation assay have been 'read across' from 2, 2', 2''-nitrilotriethanol, propoxylated. They are negative.

The results of chromosome abberation assays have been 'read across' from 2,2',2''-nitrilotriethanol, propoxylated, glycerol, propoxylated and D-glucitol, propoxylated.

For more information on the read across rationale see report from Paul Illing Consultancy Services Ltd and Marlin Consultancy (Illing and Barratt, 2007, revised 2009). The report identifies that 2, 2', 2''-nitrilotriethanol, propoxylated is the most bioavailable of the polyols linked by an ether group. Since appropriate read-across data are available, no further testing on sucrose, propoxylated is warranted. For further details concerning the groupings consult Illing and Barratt ( 2007, revised 2009).

Short description of key information:

Three in vitro mutagenicity tests using different end points were all negative. Therefore further testing is not required.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Substance does not meet criteria for classification.