Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-819-2 | CAS number: 872-05-9
In a dermal sensitisation study using Neodene 6 alpha olefin in ethanol, Duncan Hartley guinea pigs (5 animals/sex/dose) were tested using a patch sensitisation method. For the three weekly initiating doses, a 1% solution Neodene 6 alpha olefin in ethanol was applied and the primary challenge dose was also 1% Neodene 6 alpha olefin in ethanol. Preliminary tests indicate that the 1% concentration was appropriate for the challenge dose, but a dose causing mild irritation should have been chosen for the initiating dose. Reactions were scored with a numerical grade to indicate severity. The positive control provided the appropriate response. Body weight gain was not affected by treatment. Neodene 6 alpha olefin caused little or no irritation after the initiation or challenge dose and did not induce a delayed contact hypersensitivity reaction under the conditions of the study.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because although the study does not meet current OECD 406 guidelines, the study was well conducted and reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again