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EC number: 212-819-2 | CAS number: 872-05-9
No significant effects were observed at any dose level, with or without metabolic activation.
In a reverse gene mutation assay in bacteria, strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 of S. typhimurium were exposed to 1-hexene in DMSO at concentrations of 1.5, 5, 15, 50, 150, or 500 μg/plate in the presence and absence of mammalian metabolic activation using the plate-incorporation method.
1 -Hexene was tested up to cytotoxic concentrations (5000 μg/plate) in a preliminary range-finding study and based on the results, the above mentioned concentrations were tested in the mutagenicity study. No substantial increases in revertant colony numbers of any of the five tester strains were observed subsequent to treatment with 1-hexene at any dose level, either in the presence or absence of metabolic activation.There was no evidence of induced mutant colonies over background or a concentration related positive response observed during the study. The positive controls induced the appropriate responses in the corresponding strains.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it is in compliance with GLPs and an accepted concurrent guideline for reversion assays.
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