Registration Dossier
Registration Dossier
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EC number: 231-778-1 | CAS number: 7726-95-6
Endpoint summary
Administrative data
Description of key information
Bromine is classified/labelled with the symbol “C” and the risk phrase “R35”.
Dunn et al. (1967) showed that bromine is a corrosive material when applied to rabbit skin for less than one minute. A five second exposure with removal by acetone wiping produced necrosis. Severity of corrosion was increased with occlusion, even in a 10% solution. When bromine liquid was applied neat with five second washout, it was corrosive to rabbit eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Bromine is classified/labelled with the symbol “C” and the risk phrase “R35”. Data in humans have identified that minor eye irritation occurs at levels of 0.3 mg/m3.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: highly corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Bromine is classified/labelled with the symbol “C” and the risk phrase “R35”.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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