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EC number: 231-778-1 | CAS number: 7726-95-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological information
Toxicity to reproduction
Currently viewing:
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on generations indicated in Effect levels (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of Sodium Bromide in Rats: Effects on Endocrine System and Reproduction
- Author:
- Van Leeuwen F.X.R., Den Tonkelaar E.M. and Van Logten M.J.
- Year:
- 1 983
- Bibliographic source:
- Fd. Chem. Toxic., 1983, Vol. 21 no 4, 383-389.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- Study was not based on standard protocol.
Every generation was mated twice (F0 generation mated 4 times):
F0 -> F1a, F1b (further mated), F1c (for transplacental Br transport study), F1d (reversibility study)
F1b -> F2a, F2b (further mated)
F2b -> F3a, F3b
Mating of F1 and F2 generations was not performed for the 4800 or 19200 mg/kg (diet)/day dose groups. - GLP compliance:
- no
Test material
- Reference substance name:
- Sodium bromide
- EC Number:
- 231-599-9
- EC Name:
- Sodium bromide
- Cas Number:
- 7647-15-6
- IUPAC Name:
- sodium bromide
- Details on test material:
- Sodium bromide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no further details
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Diet
- Details on exposure:
- In food
Plain diet - Details on mating procedure:
- Study was not based on standard protocol.
Every generation was mated twice (F0 generation mated 4 times):
F0 -> F1a, F1b (further mated), F1c (for transplacental Br transport study), F1d (reversibility study)
F1b -> F2a, F2b (further mated)
F2b -> F3a, F3b
Mating of F1 and F2 generations was not performed for the 4800 or 19200 mg/kg (diet)/day dose groups. - Analytical verification of doses or concentrations:
- no
- Details on analytical verification of doses or concentrations:
- no further details
- Duration of treatment / exposure:
- Exposure period: Three generations
- Frequency of treatment:
- Daily
- Details on study schedule:
- no further details
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 75, 300, 1200, 4800, 19200 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- Males: 9-10 per group (F0) or 10 per group (F1, F2).
Females: 7-12 per group (F0), 14-19 per group (F1), 10 per group (F2) - Control animals:
- yes, concurrent no treatment
- Details on study design:
- no further details
- Positive control:
- no
Examinations
- Parental animals: Observations and examinations:
- Unknown method
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 300 ppm
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 1 200 ppm
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- NOAEL
- Generation:
- F2
- Effect level:
- 1 200 ppm
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables