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EC number: 271-384-7
CAS number: 68553-00-4
A distillate oil having a minimum viscosity of 900 SUS at 37.7°C (100°F) to a maximum of 9000 SUS at 37.7°C (100°F).
Information is available from several
GLP-compliant studies that have investigated the sensitisation potential
of Heavy Fuel Oil Components in the guinea pig using a closed patch
technique (Buehler method).
sensitising potential was investigated in a key study in guinea pigs
using the closed patch test procedure (API, 1980b). Ten adult male
albino guinea pigs were each treated with 0.5 mL of the test material,
three times per week for three weeks. The patches were left in place for
6 hours before removal. Two weeks after final application, they were
challenged with 0.5 mL of test material. Scores were taken at 24 hours
according to the Draize scale. A naive control group of 10 animals and a
positive control group of 10 animals were also included. The naive
control group was treated with test substance in the challenge phase
only. The positive control group was treated with a 0.05% (w/v) dilution
of dinitrochlorobenzene in both the sensitizing and challenge phases.
statistically significant difference between sensitizing and challenge
treatments for erythema and oedema was noted among the test animals, but
the challenge scores were less than the sensitizing average, indicating
that the test substance was non-sensitizing. Based on results of the
dermal challenge procedure, the test material was not considered to be a
Data are also available from multiple supporting
studies (ARCO, 1992v-aa; 1990h,i; 1989j-l; 1988b; 1986h,i, and API, 1982a;
1980a,c,d) conducted in guinea pigs. Results obtained from these studies
indicate no obvious potential for the induction or elicitation of dermal
sensitisation, however skin irritation was apparent in a number of
instances. A satisfactory response was obtained for the negative- and
positive control groups.
The results indicate that Heavy Fuel Oil
Components are not dermal sensitisers.
Migrated from Short description of key information:
Heavy Fuel Oil Components are not dermal sensitisers.
Justification for selection of skin sensitisation endpoint:
One of 18 available studies.
This endpoint is not a REACH requirement and no data are available for this endpoint but these substances are not expected to cause respiratory sensitisation.
Results from several GLP-compliant
investigations using an induction methodology that met or exceeded the
guideline requirements for skin sensitisation testing indicate that
Heavy Fuel Oil Components are not dermal sensitisers in the guinea pig.
This is consistent with knowledge of the chemistry present, which also
indicates they are unlikely to cause respiratory sensitisation. No
classification is required under the
CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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