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Physical & Chemical properties

Vapour pressure

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Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2013-02-22 to 2013-03-04
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The test substance is considered to be adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. certificate)
Remarks:
UK GLP Compliance Programme (inspected on 10 July 2012 / signed on 30 Nov. 2012)
Type of method:
gas saturation method
Specific details on test material used for the study:
- Storage condition of test material: room temperature in the dark.
Temp.:
25 °C
Vapour pressure:
7.9 Pa

Average of vapor pressure (mean of three determinations (three flow rates)):

1.95 Pa at 10°C

4.99 Pa at 20°C

12.3 Pa at 30°C

The vapor pressure curve is provided in the experimental report.

The regression parameters were calculated:

ln VP (mean in Pa) = -7904.46 / T (in K) + 28.58 (r2= 1.000)

Validation

The linearity of the detector response with respect to concentration was assessed over the concentration range of 9.70 to 485 mg/L (n=5). This was satisfactory with a correlation coefficient of 1.000 being obtained. Concentrations of sample solutions from traps 1 range between 18 and 208 mg/L, therefore within the calibration range. For traps 2 (0.17 – 0.53 mg/L), inaccuracy is considered negligible as this collected fraction represents less than 2% of the total amount.

Discussion

To ensure saturation control, three different flow rates were used at each temperature. From the data, it can be clearly seen that higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method.

Determinations were conducted at 10, 20 and 30°C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapour pressure at 25°C was interpolated from the regression.

The vapour pressure of the test material has been determined to be 7.9 Pa at 25°C.

Endpoint:
vapour pressure
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Based on structural similarity (same isomers in a different ratio) and comparing boiling points, respectively 235°C (under normal atmP) for the test substance (single isomer(cis); Harlan 2013b), and 243°C (under 101.9 kPa) for the present dossier (multiconstituent, two isomers cis/trans; Harlan 2013; please refer to IU section 4.3), both substances are not expected to have significantly different vapour pressure, or the trans isomer may have a slightly lower vapour pressure. Therefore the result of the study will be considered as a limit value for the target substance.

Further information is included in IUCLID Section 13.
Reason / purpose:
read-across source
Reason / purpose:
read-across: supporting information
Reason / purpose:
read-across: supporting information
Key result
Temp.:
25 °C
Vapour pressure:
<= 7.9 Pa
Conclusions:
(from analogue) Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the analogue test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method.

Determinations were conducted at 10, 20 and 30°C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapour pressure at 25°C was interpolated from the regression.

The vapour pressure of the test material has been determined to be 7.9 Pa at 25°C.

A similar, or slightly lower, VP is anticipated for the target substance.

Description of key information

Low volatility (from analogue).

VP = 7.9 Pa at 25°C for the cis-isomer; expected similar, or slightly lower for the trans isomer and the target reaction mass.

Key value for chemical safety assessment

Vapour pressure:
7.9 Pa
at the temperature of:
25 °C

Additional information

No data is available on the substance itself. However, a reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available on an analogue (single isomer). Comparing boiling points, minor difference is anticipated with the present dossier multiconstituent substance, the read-across is considered justified for a key study, and the result is retained as key data for purpose of CSA.