2-phenoxyethanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Reference 2

Reference Type:

publication

Title:

Final report on the safety assessment of phenoxyethanol

Author:

Anonymous

Year:

1990

Bibliographic source:

J. Am. Coll. Toxicol. 9(2): 259-277

Reference 3

Reference Type:

secondary source

Title:

Ethylene Glycol Phenyl Ether

Author:

OECD SIDS

Year:

2004

Bibliographic source:

UNEP Publications

Reference 4

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Draft IRLG (Interagency Regulatory Liaison Group) Guidelines for Selected Acute Toxicity Tests (August. 1979)

Deviations:

no

GLP compliance:

no

Remarks:

GLP was not compulsory at the time the study was performed

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethanol

EC Number:

204-589-7

EC Name:

2-phenoxyethanol

Cas Number:

122-99-6

Molecular formula:

C8H10O2

IUPAC Name:

2-phenoxyethanol

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-phenoxyethanol, "Cosmetical grade"
- Physical state: liquid
- Analytical purity: Not given, however assumed to be ca. 92% 2-phenoxyethanol, ca. 8% Diethylenglykolmonophenylether (cosmetical grade)
- Lot/batch No.: sample number: 2219-93

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Plummers Rabbit Ranch
- Weight at study initiation: 2500- 2780 g

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 24 h

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5-5.6 mL

Duration of exposure:

24 h

Doses:

2 mL/kg (corresponding to 2214 mg/kg bw; based on a density of 1.107 g/mL)

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

Test was performed on abraded skin only.
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 214 mg/kg bw