Registration Dossier

Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
An updating report on cancer among benzoyl chloride manufacturing workers
Author:
Sakabe H and Fukuda K
Year:
1977
Bibliographic source:
Ind. Health, 15: 173-174

Materials and methods

Study type:
health record from industry
Endpoint addressed:
carcinogenicity

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibenzoyl peroxide
EC Number:
202-327-6
EC Name:
Dibenzoyl peroxide
Cas Number:
94-36-0
Molecular formula:
C14H10O4
IUPAC Name:
benzoyl benzenecarboperoxoate

Method

Type of population:
occupational

Results and discussion

Applicant's summary and conclusion

Executive summary:

Two cases of lung cancer were reported among workers in a small chemical plant producing benzoyl peroxide, benzoyl chloride, and related com pounds. Both workers were exposed to benzoyl peroxyde during its manufacture, and one of them was a smoker. Other compounds to which these workers were exposed included benzoyl chloride and benzotrichloride. Based on the development of lung cancer in others occupationally exposed to these latter two compounds, the au thors suggested that there is causal association between exposure to benzoyl chloride and benzotrichloride and lung cancer. However, the study did not indicate measurement of exposure levels to these or other compounds, nor did it control for the potential influence of smoking habits or exposure to other agents. The authors draw no specific conclusions regarding the risk of benzoyl peroxide exposure, and a review of these data provides no basis for a causal link between benzoyl peroxide exposure and cancer development in the two workers discussed by Sakabe and Fukuda (1977). Rather, as indicated above, the authors attributed the cancer cases to benzoyl chloride and/ or benzoyl trichloride exposure.