Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Toxicity of Autoxidized Squalene and Linoleic Acid,|and of Simpler peroxides, in Relation to Toxicity of Radiation
Author:
Horgan, V.J., Philpot, J. ST L., Porter, B.W. and Roodyn ,|D.B.
Year:
1957
Bibliographic source:
Biochem. J., 67, 551 ~ 558, 1957

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibenzoyl peroxide
EC Number:
202-327-6
EC Name:
Dibenzoyl peroxide
Cas Number:
94-36-0
Molecular formula:
C14H10O4
IUPAC Name:
benzoyl benzenecarboperoxoate
Details on test material:
Recrystallized benzoyl peroxide

Test animals

Species:
mouse
Strain:
other: R, CBA

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
213 mg/kg bw

Any other information on results incl. tables

20 umoles/mouse equivalent to 4.84 mg/mouse or 213 mg/kg bw

Applicant's summary and conclusion