Registration Dossier
Registration Dossier
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EC number: 233-054-0 | CAS number: 10026-04-7
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1997
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- respiratory irritation
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicon tetrachloride
- EC Number:
- 233-054-0
- EC Name:
- Silicon tetrachloride
- Cas Number:
- 10026-04-7
- Molecular formula:
- Cl4Si
- IUPAC Name:
- tetrachlorosilane
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: 27 humans
- Sex: Six male (no information on other 21)
- Age: Six males were 25-56 years old
- Race: No data
- Demographic information: 5/6 were smokers
- Known diseases: No data
- Other: Six males treated at medical clinic, 21 treated at local hospital emergency department (not followed) - Route of exposure:
- inhalation
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- The symptoms experienced by exposed personnel were remarkably similar and consisted of lacrimation, rhinorrhea, burning in mouth and throat, headache, coughing and mild wheezing. In most cases, symptoms resolved within 24 hours. There was an indication of mild, obstructive airway disease in 4/6 employees at the clinic. This might have been a pre-existing condition, related to smoking, obesity or asthma and was still detectable at follow-up carried out during the year after the accident.
- Outcome of incidence:
- The symptoms experienced included lacrimation, rhinorrhea, burning in mouth and throat, headache, coughing and mild wheezing. In most cases, symptoms resolved within 24 hours.
Applicant's summary and conclusion
- Conclusions:
- Following the release of liquid silicon tetrachloride, and thereafter formation of a hydrogen chloride cloud, employees (six males) appeared to suffer from respiratory irritation (reliability score 4). In most cases, symptoms resolved within 24 hours. There was an indication of mild, obstructive airway disease in 4/6 employees at the clinic. This might have been a pre-existing condition, related to smoking, obesity or asthma, and was still detectable at follow-up carried out during the year after the accident.
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