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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published non-standard Russian study: translation provided.
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
On the Toxicity of Dimethyl Terephthalate
Sanina YP & Kochetkova TA
Bibliographic source:
Toksikol. Novykh. Prom. Khim. Veshchestv, 5, 107-123 (1963)

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
The effect of a single inhalation exposure to terephthalate vapour was tested on rats. The animals were placed for two hours into a 100-L hexahedral chamber.
GLP compliance:
: older study, pre-dates GLP
Test type:
other: non-standard design using a 2-hour exposure
Limit test:

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl terephthalate
EC Number:
EC Name:
Dimethyl terephthalate
Cas Number:
Molecular formula:
dimethyl terephthalate
Details on test material:
Dimethyl terephthalate crystals

Test animals

not specified
not specified
Details on test animals or test system and environmental conditions:
White rats were used in all the inhalation studies. A 100 L hexahedral chamber was used as the exposure chamber in all tests.

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
other: unchanged (no vehicle)
Details on inhalation exposure:
Dimethyl terephthalate vapours were generated by heating dimethyl terephthalate crystals in a metal vessel on an electric stove at 100 to 110°C. Dimethyl terephthalate vapours were delivered via a tube into the top of the exposure chamber containing the animals. The temperature in the chamber ranged from 25 to 29ºC.

In the single exposure experiment, the rats were exposed to the vapours for 2 hours.

Based on the thermal properties of dimethyl terephthalate (melting and boiling at 141 and 284°C, respectively, without reported evidence of decomposition), it is unlikley that thermal decomposition products were formed by the procedure used to generate the inhalation atmosphere.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
2 h
6 mg/L
No. of animals per sex per dose:
12 rats werere used (6 in the experiment and 6 as a control)
Control animals:
Details on study design:
Single exposure experiment: Twelve white rats (six used in experiment, six used as a control) were exposed to dimethyl terephthalate vapours for two hours. During this two hours, the rats were observed. Post exposure observation lasted for 14 days.
No further details

Not reported.

Results and discussion

Preliminary study:
No preliminary study
Effect levels
not specified
Dose descriptor:
Effect level:
> 6 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
2 h
Remarks on result:
other: No deaths
No mortalities
Clinical signs:
other: Ten to twenty minutes after being subjected to the action of dimethyl terephthalate, the animals were in an excited state (they rubbed their noses vigorously, their eyes were closed). This state lasted until the end of exposure. Acute conjunctival hyper
Body weight:
No abnormality in body weight compared to the control group was noted in the test animals.
Gross pathology:
No autopsies performed.
Other findings:
A peripheral blood analysis revealed changes in the red blood; the haemoglobin content was lower by 15 to 25% on average and the erythrocyte count decreased from 9,000,000 to 7,000, 000 to 6,000,000 to 5,000,000.

Any other information on results incl. tables

No further information.

Applicant's summary and conclusion

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: EU
During single exposure to condensation aerosol and vapours of dimethyl terephthalate a pronounced irritating effect on the conjunctiva and respiratory tract accompanied by moderate hemodynamic disorders was observed. The LC50 was estimated to be greater than 6 mg/L.
Executive summary:

In a published acute inhalation toxicity study, a group of 12 rats was exposed (whole body) to DMT vapour at a concentration of 6 mg/L for 2 hours. During the exposure to condensation aerosol and vapours of dimethyl terephthalate a pronounced irritating effect on the conjunctiva and respiratory tract accompanied by moderate hemodynamic disorders was observed. The LC50 was estimated to be greater than 6 mg/L.