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For the evaluation of the aquatic toxicity of Fusel oil, studies conducted with the main constituents of the substance, 2 -Methylbutanol (CAS No. 137-32-6), Ethanol (CAS No. 64-17-5), 3-Methylbutanol (CAS No. 123-51-3) and 2-Methylpropanol (CAS No. 78-83-1) were used.

Short-term studies on freshwater species of three trophic levels (fish, invertebrates and algae) are available for 2 -Methylbutanol (CAS No. 137-32-6) and Ethanol (CAS No. 64-17-5). The acute data (LC/EC50) for the three trophic levels were in the range of > 120 – 15300 mg/L. The available LC/EC50-values for fish, invertebrates and aquatic algae were within the same range.

In addition to the experimental data, QSAR-calculations were prepared for all main consitutents of Fusel oil. For fish and daphnids the LC/EC50 -values were above 100 mg/L for the four constituents. In case of algae, EC50-values between 50 and > 100 mg/L could be calculated. The lowest EC50 -values determined for 2 -Methylbutanol and 3 -Methybutanol was 53.05 mg/L.

In case of long-term effects, studies are available for invertebrates and algae for 2 -Methylbutanol (CAS No. 137-32-6) and Ethanol (CAS No. 64-17-5). To determine the chronic effects on fish, a validate QSAR for Ethanol (CAS No. 64-17-5) is given. Comparing the long-term data of the three trophic levels, invertebrates seem to be the most sensitive organisms. The lowest NOEC for daphnids given for Ethanol (CAS No. 64-17-5) is 9.6 mg/L for the relevant parameter reproduction.

Effects on microorganisms were evaluated on 2 -Methylbutanol (CAS No. 137-32-6) and Ethanol (CAS No. 64-17-5) resulting in EC5/10-values of 65 – 470 mg/L.

No studies on the toxicity to fish, invertebrates and aquatic algae are available for 3-Methylbutanol (CAS No. 123-51-3) and 2-Methylpropanol (CAS No. 78-83-1). 3 -Methylbutanol is structurally very similar to 2-Methylbutanol; both are branched primary aliphatic alcohols with five carbons. The structure of 2 -Methylpropanol only differs from 2 -Methylbutanol by the one carbon shorter chain length. The ecotoxicological profile is thus expected to be similar for the three constituents, which is supported by the performed QSAR calculations.