Registration Dossier
Registration Dossier
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EC number: 232-395-2 | CAS number: 8013-75-0 A combination of amyl alcohols, primarily isoamyl alcohol and 2-methyl-1-butanol. Other alcohols, acids, esters and aldehydes may also be present.
Endpoint summary
Administrative data
Description of key information
Additional information
For the evaluation of the aquatic toxicity of Fusel oil, studies conducted with the main constituents of the substance, 2 -Methylbutanol (CAS No. 137-32-6), Ethanol (CAS No. 64-17-5), 3-Methylbutanol (CAS No. 123-51-3) and 2-Methylpropanol (CAS No. 78-83-1) were used.
Short-term studies on freshwater species of three trophic levels (fish, invertebrates and algae) are available for 2 -Methylbutanol (CAS No. 137-32-6) and Ethanol (CAS No. 64-17-5). The acute data (LC/EC50) for the three trophic levels were in the range of > 120 – 15300 mg/L. The available LC/EC50-values for fish, invertebrates and aquatic algae were within the same range.
In addition to the experimental data, QSAR-calculations were prepared for all main consitutents of Fusel oil. For fish and daphnids the LC/EC50 -values were above 100 mg/L for the four constituents. In case of algae, EC50-values between 50 and > 100 mg/L could be calculated. The lowest EC50 -values determined for 2 -Methylbutanol and 3 -Methybutanol was 53.05 mg/L.
In case of long-term effects, studies are available for invertebrates and algae for 2 -Methylbutanol (CAS No. 137-32-6) and Ethanol (CAS No. 64-17-5). To determine the chronic effects on fish, a validate QSAR for Ethanol (CAS No. 64-17-5) is given. Comparing the long-term data of the three trophic levels, invertebrates seem to be the most sensitive organisms. The lowest NOEC for daphnids given for Ethanol (CAS No. 64-17-5) is 9.6 mg/L for the relevant parameter reproduction.
Effects on microorganisms were evaluated on 2 -Methylbutanol (CAS No. 137-32-6) and Ethanol (CAS No. 64-17-5) resulting in EC5/10-values of 65 – 470 mg/L.
No studies on the toxicity to fish, invertebrates and aquatic algae are available for 3-Methylbutanol (CAS No. 123-51-3) and 2-Methylpropanol (CAS No. 78-83-1). 3 -Methylbutanol is structurally very similar to 2-Methylbutanol; both are branched primary aliphatic alcohols with five carbons. The structure of 2 -Methylpropanol only differs from 2 -Methylbutanol by the one carbon shorter chain length. The ecotoxicological profile is thus expected to be similar for the three constituents, which is supported by the performed QSAR calculations.
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