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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Basic information is available. Only one sex was tested.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1948
Report date:
1948

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
other
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichlorosilane
EC Number:
233-042-5
EC Name:
Trichlorosilane
Cas Number:
10025-78-2
Molecular formula:
Cl3HSi
IUPAC Name:
trichlorosilane

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
0.795, 1.0, 1.26, and 1.58 g/kg (as a 10% dilution in corn oil)
No. of animals per sex per dose:
10 males/dose
Control animals:
no
Details on study design:
14-day post observation period; body weight was monitored
Statistics:
The LD50 was calculated by the method of Thompson.

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
1 030 mg/kg bw
Based on:
test mat.
95% CL:
> 890 - < 1 210
Mortality:
Mortalities of 2, 5, 7, and 9 animals out of 10 were reported for the male rats dosed on 0.795, 1.00, 1.26, and 1.58 g/kg bw, respectively.
Clinical signs:
other: No information available.
Gross pathology:
Direct injury to the gastrointestinal tract was the cause of death. The stomach and intestines haemorrhaged and where the stomach contacted the liver and kidney the latter organs had a cooked appearance.

Any other information on results incl. tables

MALES:

Dosage: 1.58 g/kg

Dead/Dosed: 9/10

Weight Change (g) in 14 days: +37 grams

Dosage: 1.26 g/kg

Dead/Dosed: 7/10

Weight Change (g) in 14 days: +38 grams to +60 grams

Dosage: 1.00 g/kg

Dead/Dosed: 5/10

Weight Change (g) in 14 days: +3 grams to +59 grams

Dosage: 0.795 g/kg

Dead/Dosed: 2/10

Weight Change (g) in 14 days: -14 grams to +38 grams

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In an acute oral toxicity study, conducted to a protocol similar to OECD Test Guideline 401 but pre-GLP, trichlorosilane was dosed as a 10% v/v dilution in corn oil. An LD50 for male albino rats was concluded to be 1030 mg/kg bw (890 to 121 mg/kg bw). No clinical observations were specified. Observations from necropsy indicated that direct injury to the gastrointestinal tract was the cause of death. The stomach and intestines haemorrhaged and where the stomach contacted the liver and kidney, the latter organs had a cooked appearance.