Registration Dossier
Registration Dossier
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EC number: 233-042-5 | CAS number: 10025-78-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 946
- Report date:
- 1946
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 24-hour exposure in rabbit belly vesicant test.
- GLP compliance:
- no
Test material
- Reference substance name:
- Trichlorosilane
- EC Number:
- 233-042-5
- EC Name:
- Trichlorosilane
- Cas Number:
- 10025-78-2
- Molecular formula:
- Cl3HSi
- IUPAC Name:
- trichlorosilane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 5
- Remarks on result:
- other: not specified
- Irritation parameter:
- edema score
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 5
- Remarks on result:
- other: not specified
- Irritant / corrosive response data:
- An erythema/oedema score of 2 out of a maximum of 5 was reported.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In an in vivo skin irritation toxicity study, not conducted according to OECD Test Guideline or GLP, an erythema/oedema score of 2 out of a maximum of 5 was reported in a summary table of results of a rabbit belly vesicant tests.
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