Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951
Reference Type:
study report
Title:
Unnamed
Year:
1946
Report date:
1946

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
24-hour exposure in rabbit belly vesicant test.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichlorosilane
EC Number:
233-042-5
EC Name:
Trichlorosilane
Cas Number:
10025-78-2
Molecular formula:
Cl3HSi
IUPAC Name:
trichlorosilane

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Time point:
24 h
Score:
2
Max. score:
5
Remarks on result:
other: not specified
Irritation parameter:
edema score
Time point:
24 h
Score:
2
Max. score:
5
Remarks on result:
other: not specified
Irritant / corrosive response data:
An erythema/oedema score of 2 out of a maximum of 5 was reported.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
In an in vivo skin irritation toxicity study, not conducted according to OECD Test Guideline or GLP, an erythema/oedema score of 2 out of a maximum of 5 was reported in a summary table of results of a rabbit belly vesicant tests.