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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1946
Report date:
1946
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichlorosilane
EC Number:
233-042-5
EC Name:
Trichlorosilane
Cas Number:
10025-78-2
Molecular formula:
Cl3HSi
IUPAC Name:
trichlorosilane

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Amount / concentration applied:
1% and 5% dilutions in "Deobase" (deodorized kerosene) were evaluated by instillation into rabbits' eyes.
3-minute exposures to 250 and 500 ppm dose levels were evaluated.

Results and discussion

In vivo

Results
Irritation parameter:
other:
Remarks on result:
other:
Remarks:
5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes. 1% dilution produced minor damage. The compound is relegated to grade 9 in a 10-grade rating system for eye burns. A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later. This was considered as a delayed burn.

Any other information on results incl. tables

5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes 

1% dilution produced minor damage. 

The compound is relegated to grade 9 in a 10-grade rating system for eye burns 

A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later. This was considered as a delayed burn.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an in vivo eye irritation study, not conducted according to OECD Test Guideline or GLP, 5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes whereas 1% dilution produced minor damage. The compound was relegated to grade 9 in a 10-grade rating system for eye burns. A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later and considered as a delayed burn.