Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-042-5 | CAS number: 10025-78-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 946
- Report date:
- 1946
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
Test material
- Reference substance name:
- Trichlorosilane
- EC Number:
- 233-042-5
- EC Name:
- Trichlorosilane
- Cas Number:
- 10025-78-2
- Molecular formula:
- Cl3HSi
- IUPAC Name:
- trichlorosilane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Amount / concentration applied:
- 1% and 5% dilutions in "Deobase" (deodorized kerosene) were evaluated by instillation into rabbits' eyes.
3-minute exposures to 250 and 500 ppm dose levels were evaluated.
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Remarks on result:
- other:
- Remarks:
- 5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes. 1% dilution produced minor damage. The compound is relegated to grade 9 in a 10-grade rating system for eye burns. A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later. This was considered as a delayed burn.
Any other information on results incl. tables
5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes
1% dilution produced minor damage.
The compound is relegated to grade 9 in a 10-grade rating system for eye burns
A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later. This was considered as a delayed burn.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an in vivo eye irritation study, not conducted according to OECD Test Guideline or GLP, 5% dilution in "Deobase" (deodorized kerosene) ruined rabbit eyes whereas 1% dilution produced minor damage. The compound was relegated to grade 9 in a 10-grade rating system for eye burns. A 3-minute exposure of rabbit eyes to 500 ppm of vapor produced immediate opacity of the cornea. A concentration of 250 ppm gave no damage that was immediately detectable, but which become apparent 3 hours later and considered as a delayed burn.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
