Registration Dossier
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EC number: 203-630-6 | CAS number: 108-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- other: statistical review
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Statistical approach to available data, however, no attempt was made weight individual reported melting points for quality.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The mean melting point was calculated for multiple measurements reported in the literature.
- GLP compliance:
- no
- Type of method:
- other: statistical review
- Melting / freezing pt.:
- 24.1 °C
- Atm. press.:
- ca. 1 atm
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: 95%C.I. 23.67-24.54°C
- Conclusions:
- The mean literature melting point for cyclohexanol is 24.10 °C (23.67 – 24.54 °C). In addition to experimental uncertainty in the temperature measurement, the above statistical value can be expected to encompass variation due to sample purity, and unrecognised polymorphism. Bias introduced by data recycling cannot be excluded, but has been attempted to be controlled for, although without inspection of every literature reference.
Reference
Description of key information
24.10 °C (23.67 – 24.54 °C), statistical review
25.5-25.6 °C, Nitta 1948
25.62 °C, Hennings 1962
25.90 °C ±0.03 °C, Adachi 1968
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 24.1 °C
Additional information
A survey of available literature data was carried out for the melting point. The potential data sources were restricted to two bibliographic databases, augmented by data from studies previously identified as having high-quality results for other physico-chemical endpoints. No attempt was made to weight individual studies by reliability, instead a statistical approach was taken. Data from obvious secondary sources, and multiple reports of a numerically equivalent melting point by the same authors, were discarded as potential sources of bias due to data recycling. The mean melting point and confidence interval was calculated.
Three references with known high purity (Nitta, Hennings, Adachi) were reported with melting point somewhat higher than the mean value. This could be a reflection of melting point depression due to impurities, or potentially a result of unrecognised polymorphs in the literature.
The mean value is taken forward for the purposes of risk assessment, as being most representative of the commercial substance. The available data is considered to be relevant, reliable, and adequate for risk assessment purposes. The endpoint is considered complete, in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.1.1.
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