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Registration Dossier
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EC number: 200-838-9 | CAS number: 75-09-2
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: study with unclear GLP-status, peer-reviewed summary under auspices of WHO, restrictions in reporting
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Methylene Chloride (2nd ed)
- Author:
- WHO
- Year:
- 1 996
- Bibliographic source:
- Environmental Health Criteria 164
- Reference Type:
- publication
- Title:
- Methylene chloride and chronic renal hypertension
- Author:
- Loyke HF
- Year:
- 1 973
- Bibliographic source:
- Arch Pathol 95 (2), 130-131
Materials and methods
- Principles of method if other than guideline:
- Not specified, but the review docuements (ECH 1996) considered the study results reliable/acceptable
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloromethane
- EC Number:
- 200-838-9
- EC Name:
- Dichloromethane
- Cas Number:
- 75-09-2
- Molecular formula:
- CH2Cl2
- IUPAC Name:
- dichloromethane
- Details on test material:
- Not specified, but the review docuements (ECH 1996) considered the study results reliable/acceptable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 17 weeks
- Frequency of treatment:
- twice a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/kg bw
Basis:
Results and discussion
- Details on results:
- LOAEL = 2000 mg/kg bw (2 times/week for 17 weeks)
Any other information on results incl. tables
Reduction of the systolic blood pressure of hypertensive Sprague- Dawley rats was reported after subcutaneous exposure to 2000 mg/kg twice a week for 17 weeks. No effect was found in normotensive rats. Very slight histopathological changes in the liver and lungs of hypertensive rats were described.
Applicant's summary and conclusion
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