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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

The key study (Melo et al., 2019) showed a 48h-EC50 of 74.2 mg/L.

This is supported by an older study (Hantink-de Rooy and Balk, 1985) that showed a 48h-EC50 of 88 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
74.2 mg/L

Additional information

Two valid non-GLP studies with restriction are available. One study performed in 1985 (Hantink-deRooy and Balk), before standardized test guidelines were available. A static acute test was performed without chemical analyses. A study performed in 2019 ( Melo, et al.) is also available. This study was performed according to OECD guideline 202 with chemical analyses. No details on analytical method were given in the publication, but it was shown that test concentrations were stable and stayed within 80 -120% of nominal.

Both studies gave similar results: The first study gave a 48h-EC50 of 88 mg/L (nominal) and the second study gave a 48h-EC50 of 74.2 mg/L (nominal).