Registration Dossier
Registration Dossier
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EC number: 201-178-4 | CAS number: 79-11-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monochloroacetic acid toxicity in the mouse associated with blood-brain barrier damage
- Author:
- Berardi
- Year:
- 1 986
- Bibliographic source:
- Dissertation, Rutgers The State U. of N.J. - New Brunswick and U.M.D.N.J., May1986 (Abstract: Ref.167)
- Reference Type:
- publication
- Title:
- EU RAR MCAA
- Author:
- EU RAR
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- monochloroacetic acid
- IUPAC Name:
- monochloroacetic acid
- Details on test material:
- not specified
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 1-14C-MCAA
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- Pre-treatment for 2 minutes with 400 mg/kg molten (65C) MCAA
3 minutes 0.6 mg/kg 1-14C-MCAA - Doses:
- Pre-treatment for 2 minutes with 400 mg/kg molten (65C) MCAA
3 minutes 0.6 mg/kg 1-14C-MCAA - No. of animals per group:
- not specified
- Control animals:
- no
- Details on study design:
- With or without pre-treatment of the skin with 400 mg/kg molten (65C) MCAA before treatment for 3 minutes with 0.6 mg/kg 1-14C-MCAA. Different temperature 25 compared to 65 degrees.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- no data
- Total recovery:
- no data
Applicant's summary and conclusion
- Conclusions:
- Significant increase in absorption after pre-treament of the skin with molten MCAA. No significant difference in radioacitivity in plasma, whole brain, skin and urine of mice comparing the 65 and 25 degree solution after 6 hours.
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