Registration Dossier

Toxicological information

Dermal absorption

Currently viewing:

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monochloroacetic acid toxicity in the mouse associated with blood-brain barrier damage
Author:
Berardi
Year:
1986
Bibliographic source:
Dissertation, Rutgers The State U. of N.J. - New Brunswick and U.M.D.N.J., May1986 (Abstract: Ref.167)
Reference Type:
publication
Title:
EU RAR MCAA
Author:
EU RAR
Year:
2005

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
not specified
Radiolabelling:
yes
Remarks:
1-14C-MCAA

Test animals

Species:
mouse
Strain:
Swiss Webster
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
Pre-treatment for 2 minutes with 400 mg/kg molten (65C) MCAA
3 minutes 0.6 mg/kg 1-14C-MCAA
Doses:
Pre-treatment for 2 minutes with 400 mg/kg molten (65C) MCAA
3 minutes 0.6 mg/kg 1-14C-MCAA
No. of animals per group:
not specified
Control animals:
no
Details on study design:
With or without pre-treatment of the skin with 400 mg/kg molten (65C) MCAA before treatment for 3 minutes with 0.6 mg/kg 1-14C-MCAA. Different temperature 25 compared to 65 degrees.

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not specified
Absorption in different matrices:
no data
Total recovery:
no data

Applicant's summary and conclusion

Conclusions:
Significant increase in absorption after pre-treament of the skin with molten MCAA. No significant difference in radioacitivity in plasma, whole brain, skin and urine of mice comparing the 65 and 25 degree solution after 6 hours.