Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-164-5 | CAS number: 17095-24-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The prediction has been carried out by means of QSAR prediction, using the following
models:
“Leadscope Enterprise model for severe skin irritation in vivo, Danish QSAR
Group at DTU Food”. The relative QMRF is available as attached file (7.3.1 -
EC 241-164-5 - RB5 - LeadScope - QMRF.pdf)
“SciMatics SciQSAR model for severe skin irritation in vivo, Danish QSAR
Group at DTU Food”. The relative QMRF is available as attached file (7.3.1 -
EC 241-164-5 - RB5 - SciQSAR - QMRF.pdf)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 020
Materials and methods
- Principles of method if other than guideline:
- In-Silico prediction (QSAR) has been used to cover the present endpoint. The aim of this prediction is to contribute through a weight of evidence approach to the assessment of the skin irritation/corrosion potential in order to satisfy the REACH requirements for the registration dossier using non-testing methods.
A total of two independent QSAR models have been applied.
Test material
- Reference substance name:
- Tetrasodium 4-amino-5-hydroxy-3,6-bis[[4-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]azo]naphthalene-2,7-disulphonate
- EC Number:
- 241-164-5
- EC Name:
- Tetrasodium 4-amino-5-hydroxy-3,6-bis[[4-[[2-(sulphonatooxy)ethyl]sulphonyl]phenyl]azo]naphthalene-2,7-disulphonate
- Cas Number:
- 17095-24-8
- Molecular formula:
- C26H25N5O19S6.4Na
- IUPAC Name:
- tetrasodium 4-amino-5-hydroxy-3,6-bis[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vivo
Results
- Remarks on result:
- other: Both applied models predict the test material as NOT a severe skin irritant. The test material fulfils the model’s applicability domain, satisfying the defined reliability criteria.
Any other information on results incl. tables
The test material QPRF for the Leadscope model is available as attached file (7.3.1 - EC 241-164-5 - RB5 - LeadScope - QPRF.pdf).
The test material QPRF for the SciQSAR model is available as attached file (7.3.1 - EC 241-164-5 - RB5 - SciQSAR - QPRF.pdf)
The output report automatically generated by the Danish QSAR database is available as attached file (7.3.1 - EC 241-164-5 - RB5 - Prediction.pdf) – The report contains both the results for the SciQSAR model and the LeadScope model.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Both applied models predict the test material as NOT a severe skin irritant.
The test material fulfils the model’s applicability domain, satisfying the defined reliability criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
