Registration Dossier
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EC number: 229-146-5 | CAS number: 6419-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Remarks:
- Identification of degradation products
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- In dilute aqueous conditions of defined pH, a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present, and will be fully dissociated. Hence some properties (measured or expressed in aqueous media, e.g. ecotoxicity) for a salt can be directly read across (with suitable mass correction) to the parent acid and vice versa. In the present context the effect of the counter-ion will not be significant.
In the environment, the salt form is immaterial and speciation will occur in natural media. Similarly for all environmental related endpoints, use of buffered test media results often reflect a salt speciation relevant for ~pH7 only and it would be impossible to test specific salts associated with high and low pH.
Detaching or attracting a proton does not change the chemical safety assessment of the molecule as long as no other part of the molecular skeleton is changed, because in studies or when there is exposure, the pH will control the identity of the form or forms present.
Almost all natural waters contain more ions than the usual PEC values of the phosphonates. - Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (DOC removal)
- Value:
- 0
- Sampling time:
- 28 d
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge from HRC sewage treatment plant. The nature of the influent to this treatment plant is not known. Filtered through Whatman No. 1 paper (first 200 ml discarded).
- Storage conditions: Filtrate kept aerated until used - Duration of test (contact time):
- 28 d
- Details on study design:
- TEST CONDITIONS
- Composition of medium: The carbon content of each sample was calculated from the empirical formula and sufficient added to 2 litre medium to give a nominal carbon content of 40 mg/l. The solution was then spli into two 1 litre replicates and inoculated. Inoculum usage rate: 0.5 ml/l
- Test temperature: 22 °C nominal. Temperatures were recorded daily and evaporative losses made up with distilled water.
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 1 litre glass beakers. Agitation; by magnetic stirrer. Colling; by cold finger condenser.
SAMPLING
- Sampling frequency: 0, 7, 14, 21, 27, 28 d.
- Sampling method: Samples (25-30 ml) were withdrawn from each test vessel and filtered through millipore GS 0.22 µm disposable filters, discarding the first 15-20 ml. The 10 ml samples were stored frozen if not analysed imediately. - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 0
- Sampling time:
- 28 d
- Conclusions:
- A ready biodegradation rate of 0% in 28d was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Referenceopen allclose all
Table 1: Dissolved organic carbon levels (mg/l) and calculated % bioelimination
Type of suspension |
| Day 0 | Day 7 | Day 14 | Day 21 | Day 27 | Day 28 |
Test Sample | DOC (mg/l) | 44 | 44 | 42 | 45 | 52 | 51 |
Test Sample | Bioelimination (%) | - | 0 | 5 | 0 | 0 | 0 |
Reference substance | DOC (mg/l) | 33 | 7 | 5 | 1 | 2 | 1 |
Reference substance | Bioelimination (%) | - | 79 | 85 | 97 | 94 | 97 |
Description of key information
ATMP and its salts are not readily biodegradable, based on 0 - 23% degradation in 28 days in reliable ready biodegradability studies.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
A reliable ready biodegradability study is available (OECD 301E, Douglas and Pell 1984), indicating 0% biodegradation in 28 days based on DOC removal.
A second reliable ready biodegradability study using pre-adapted inoculum (OECD 301D, Cremers and Hamwijk, 2006) indicated 22 -23% biodegradation in 28 days based on O2 consumption. (Note: This is a standard study with some acceptable deviations: pre-adapted inoculum was used and inorganic phosphate was omitted from the nutrient medium. In addition, solutions of test substance stock solution were made in natural seawater).
A reliability 2 SCAS test study is also available (Saeger et al. 1978). However, SCAS tests are generally considered less reliable than ready biodegradability tests. No statistically significant degradation was observed.
A reliable anaerobic biodegradability study (Zeneca Brixham Environmental Laboratory, 1995) indicated a biodegradation rate of 0 - 21% in 28d.
Furthermore, the results of three biodegradability in seawater studies (Drake, 2005, Rowlands, 2005 and Hamwijk and Cremers, 2005) (refer to Section 5.2.2) support the conclusion that the substance is not expected to be readily biodegradable.
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