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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
An experimental study on the neurotoxicity of n-hexane metabolites: Hexanol-1 and hexanol-2.
Author:
Perbellini L. et al
Year:
1978
Bibliographic source:
Toxicol Appl Pharmacol. 46(2): 421-427

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexan-1-ol
EC Number:
203-852-3
EC Name:
Hexan-1-ol
Cas Number:
111-27-3
Molecular formula:
C6H14O
IUPAC Name:
hexan-1-ol
Details on test material:
1-hexanol >98% pure

Test animals

Species:
rat
Strain:
Sprague-Dawley

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
30 weeks
Frequency of treatment:
Daily, 6 days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
102.5 mg/kg/day
Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: None

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

This study was carried out to investigate the possible peripheral neurotoxicity of 1-hexanol (and 2-hexanol) known metabolites of the known peripheral neurotoxin n-hexane.

1-hexanol did not produce the typical EMG alterations observed with n-hexane and in particular the distal motor latency was unchanged. There were 
also no clear cut abnormalities of the peripheral nerve. The relevance of the decrease in sensory conduction velocity is unclear.

Applicant's summary and conclusion

Conclusions:
This neurophysiological investigation in rats following long term exposure to 1-hexanol indicates that 1-hexanol (n-hexane metabolite) does not produce the typical changes in EMG characteristic of peripheral neuropathy induced by n-hexane.