Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-867-7 | CAS number: 75-38-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.15 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1.5 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.015 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.718 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 5.43 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Using validated QSAR models from ECOSAR™ v0.99 (U.S. EPA, 2001), the 96-h LC50 in freshwater fish is 246 mg/L, the 48-h LC50 in daphnids is 250 mg/L and the 96-h EC50 in green algae is 150 mg/L (the QMRFs and QPRFs can be found in Annexes 9 to 14). No data are available for micro-organisms, but emission to waste water is not expected.
Conclusion on classification
Initial EU and GHS hazard classification
According to Directive 67/548/EEC, results of validated structure activity relationships and expert judgment may also be taken into account where appropriate with regard to classification and labelling of substances.
Based on all available ecotoxicological data for daphnids, fish and algae, VDF not need to be classified according to Directive 67/548/EEC since the lowest estimated effect concentration is 150 mg/L in green algae. And although VDF is not expected to be readily biodegradable based on results with structural analogues, the substance is not bioaccumulative based on its low log Kow of 1.24.
According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 VDF needs not to be labelled for the same reasons as stated above.
8. PBT AND VPVB ASSESSMENT
8.1. Assessment of PBT/vPvB Properties - Comparison with the Criteria of Annex XIII
An assessment of the PBT status of VDF has been made using all available data. The information available suggests that VDF does not meet the PBT screening criteria as outlined in Directive 2006/121/EC (see Appendix A for the criteria).
8.1.1. Persistence Assessment
No data on biodegradability is available. Information from related gaseous materials (pentafluoroethane and vinylidine chloride) generally showed ≤ 5% degradation (SIDS, 2005 and NITE, 1992) Based on these analogous substances, VDF is not expected to be readily biodegradable (see Annex 4 for the Reporting Format). However, it was demonstrated that indirect photodegradation can contribute significantly to the rapid degradation of VDF in the environment. Furthermore, VDF partition mainly to air and the photodegradation in the atmospheric compartment is expected to be fast (the DT50 of VDF, based on a 12-hr day with an OH radical concentration of 1.5E6 OH/cm3, is 4.7 days). Therefore it can be stated that the P criterion is not met for this substance.
8.1.2. Bioaccumulation Assessment
No measured BCF results are available. The potential for bioaccumulation was therefore assessed on the basis of the log Kow using the program BCFWIN™ v3.00 (U.S. EPA, 2009). The model shows no bioaccumulative potential for VDF (BCF is 3.06 L/kg). Further testing in scope of the PBT assessment is therefore not considered necessary.
8.1.3. Toxicity Assessment
No measured aquatic toxicity data are available for VDF; therefore ECOSAR™ v0.99 (U.S. EPA, 2001) was applied. The calculated acute effect data for all three trophic levels (fish, invertebrates, algae) are much higher than 0.1 mg/l (the lowest calculated effect concentration is a 96-h EC50 of 150 mg/L in green algae). It can therefore be expected that VDF is not potentially toxic towards aquatic organisms. At this moment, there is no reason to expect a CMR classification for VDF, as the substance is not classified as being carcinogenic and there is no evidence that VDF is chronically toxic towards mammals. Therefore, the T-criterion is not fulfilled, and further testing in scope of the PBT assessment is not necessary.
8.1.4. Summary and overall Conclusions on PBT or vPvB Properties
The overall conclusions, based on the present available data, of the preliminary PBT assessment are that the (screening) criteria for PBT/vPvB are not met and that further testing in the scope of the final PBT assessment is not considered to be required.
8.2. Emission Characterisation
VDF is not a PBT/vPvB substance; therefore the emission characterisation does need not to be conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.